THE ITALIAN NETWORK Italian National Institute of Health Institute for Pharmacological Research - IRCCS "Mario Negri" , Milan and Bergamo Department of Medical and Surgical Sciences, Alma Mater Studiorum - University of Bologna, Bologna University of Milan - Bicocca, Milan; Institute for the Study, Prevention and Oncology Network (ISPRO) Tuscany, Florence Regional Health Agency of Tuscany, Florence Department of Public Health, University of Naples Federico II, Naples Department for Health Activities and Epidemiological Observatory (DASOE) of the Regional Department of Health, Sicily Region, Palermo, Italy ATS Pavia - Dept. Hygiene and Health Prevention, Environmental Epidemiology Operational Unit, Pavia Health Protection Agency IRCCS "Carlo Besta" Neurological Institute Foundation, Milan Department of Clinical and Community Sciences (DISCCO) IRCCS Istituto Neurologico Mediterraneo, Pozzilli (IS) IRCCS Materno Infantile Burlo Garofolo Department of Translational Biomedicine and Neuroscience, University of Bari "Aldo Moro" Tuscany center USL company Department of Legal and Economic Studies, University of Rome "La Sapienza," Rome Center for Neurodegenerative Diseases of the Ente Ecclesiastico Pia Fondazione di Culto e Religione "Card. G. Panico," Tricase (LE) GISED Study Center, Bergamo CNR Institute of Neuroscience, Padua, Italy Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy. Health and Social Agency of the Emilia-Romagna Region, Bologna CPO Piedmont - SSD epidemiology and screening. AOU City of Health and Science of Turin Department of Biomedical, Dental and Morphological and Functional Imaging Sciences, University of Messina THE GLOBAL NETWORK Institute for Health Metrics and Evaluation COST Action CA18218 - European burden-EU of disease network.